Stem Cell and Liver Regeneration

✍ Scribed by Hiroshi Nishina, Tomomi Watanabe, Kentaro Nakagawa (auth.), Kiwamu Okita M.D., Ph.D. (eds.)

• Publisher: Springer Tokyo
• Year: 2004
• Tongue: English
• Leaves: 95
• Edition: 1
• Category: Library

✦ Synopsis

Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.

✦ Table of Contents

Front Matter....Pages II-XI
SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis....Pages 1-14
Promising Resources of Hepatic Progenitor Cells....Pages 15-25
Oncostatin M Promotes Differentiation of Fetal Hepatocytes in vitro and Regulates Liver Regeneration in vivo....Pages 26-35
Hepatocyte Growth Factor Accelerates Proliferation of Hepatic Oval Cells in a 2-Acetylaminofluorene/Partial Hepatectomy Model in the Rat....Pages 36-40
Stem Cells and Liver Repopulation: Current Reality and Prospects for the Future....Pages 41-50
Strategy for the Development of Cell Therapy Using Bone Marrow Cells to Repair Damaged Liver....Pages 51-56
Bcl-xL as a Critical Apoptosis Antagonist in Hepatocytes and Hepatocellular Carcinoma....Pages 57-64
Dedifferentiation and Proliferation of Hepatocellular Carcinoma: From Early to Advanced....Pages 65-73
Genome-Wide Analysis of Gene Expression in Hepatocellular Carcinoma....Pages 74-83
Back Matter....Pages 85-87

✦ Subjects

Hepatology