Cardiovascular Regeneration and Stem Cell Therapy

✍ Scribed by Annarosa Leri MD, Piero Anversa MD, William H. Frishman MD

Publisher: Wiley-Blackwell
Year: 2007
Tongue: English
Leaves: 244
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers:

The biology of stem cells
The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels
How stem cells could contribute to myocardial recovery in the face of injury and aging
How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair
Clinical applications and clinical experiences

This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

✦ Table of Contents

Cardiovascular Regeneration and Stem Cell Therapy......Page 1
Contents......Page 7
Contributors......Page 9
Preface......Page 13
Introduction......Page 15
Part I Stem cell biology......Page 17
1 Homing of stem cells and tissue injury......Page 19
2 Adult stem cell plasticity: lineage potential on a continuum......Page 25
3 Embryonic stem cells and cardiogenesis......Page 39
4 Mesenchymal stem-cell-derived cardiomyogenic cells......Page 51
5 Bone marrow cells and vascular growth......Page 61
6 Progenitor cells and vascular repair......Page 71
Part II Cardiac progenitor cells in the adult heart......Page 81
7 Cardiac side population cells: phenotype and functional significance......Page 83
8 Phenotype and function of c-kit+ -derived amplifying myocytes......Page 91
9 Cardiac stem cells and their niches......Page 101
10 Activation of the local regenerative system of the heart......Page 109
Part III Progenitor cells and the diseased heart......Page 117
11 Embryonic stem cells and myocardial regeneration......Page 119
12 Bone-marrow-derived cells in myocardial repair and regeneration......Page 131
13 Endothelial progenitor cells and the infarcted heart......Page 143
14 Cytokines and heart remodeling......Page 153
15 IGF-1, muscle progenitors, and heart failure......Page 163
Part IV Cardiac progenitor cells and heart failure......Page 173
16 Cardiac stem cells and diabetic cardiomyopathy......Page 175
17 Stem cells and cardiac aging......Page 185
18 Bioengineered scaffolds: myocytes, endothelial cells and cardiac repair......Page 197
19 Gene therapy and cellular therapy in cardiac repair......Page 207
20 Cardiac stem cells and the failing heart......Page 215
21 Myocardial infarction: risks and hope......Page 225
Part V Future directions......Page 233
22 Conclusions – future directions......Page 235
Index......Page 239

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