## Abstract Mammary cancer is among the most frequently observed canine tumors in unspayed female dogs resulting in death due to metastatic disease. These tumors are excellent models of human breast cancer but until recently there was only anecdotal evidence regarding underlying genetic defects. We
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
β Scribed by Janzen, Viktor; Forkert, Randolf; Fleming, Heather E.; Saito, Yoriko; Waring, Michael T.; Dombkowski, David M.; Cheng, Tao; DePinho, Ronald A.; Sharpless, Norman E.; Scadden, David T.
- Book ID
- 109896189
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 1013 KB
- Volume
- 443
- Category
- Article
- ISSN
- 0028-0836
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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an