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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

✍ Scribed by Janzen, Viktor; Forkert, Randolf; Fleming, Heather E.; Saito, Yoriko; Waring, Michael T.; Dombkowski, David M.; Cheng, Tao; DePinho, Ronald A.; Sharpless, Norman E.; Scadden, David T.


Book ID
109896189
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
1013 KB
Volume
443
Category
Article
ISSN
0028-0836

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an