Steady state pharmacokinetics of hydrolysed bopindolol in young and elderly men

✍ Scribed by D. Holmes; E. Nuesch; J. M. Houle; J. Rosenthaler

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 535 KB
• Volume: 41
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00265913

✦ Synopsis

Steady-state pharmacokinetic parameters of the new, long-acting beta-adrenoceptor blocker bopindolol have been measured in 17 young and 20 elderly healthy men. The t 1/2 beta and the AUC(0----24 h) of hydrolysed bopindolol (the active metabolite) were both increased (40% and 26%, respectively) in the elderly subjects but tmax, Cmax and CL/f were not altered. However, after adjusting the parameters to allow for the different average body weights of the two groups, Cmax and CL/f became significantly different (+29% and -30%, respectively). AUC(0----24 h) was increased by 41%. The changes of up to 41% in pharmacokinetic parameters were smaller than the alterations of 50-100% usually seen when titrating doses of antihypertensive drugs. The clinical relevance of the effects was not examined, but similar changes have been reported for other beta-blockers which did not appear to be clinically relevant and did not affect the dosage required to treat hypertension.