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Steady-state distribution volume in physiologic multi-organ systems

✍ Scribed by Michael Weiss

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
298 KB
Volume
4
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

A unique definition of the apparent volume of distribution at steady‐state is presented which is consistent with the realistic concept of blood concentration differences within the circulatory system. A physiologically based pharmacokinetic model consisting of eliminating and non‐eliminating organs is used to predict the effect of drug elimination upon the steady‐state distribution volume.

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