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Status of liposomes as MR contrast agents

✍ Scribed by Evan C. Unger; De-Kang Shen; Thomas A. Fritz

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
417 KB
Volume
3
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Recent work on the development of liposomal magnetic resonance (MR) contrast agents has yielded structures with higher overall relaxivity than that of other nanoparti‐cles of similar diameter. Liposomes incorporating membrane‐bound complexes of manganese (“memsomes”) produce greater hepatic enhancement per micromole of metal ion than either ferrite particles or paramagnetic chelates. Memsomes also hold promise for targeting of sites outside the liver. Work is in progress to take these agents into clinical trials.

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