Statistically Based Reduced Representation of Amino Acid Side Chains.
✍ Scribed by Jan K. Rainey; M. Cynthia Goh
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 78 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
The conformational freedom of amino acid side chains is strongly reduced when the side chains occur on an a-helix. A quantitative evaluation of this freedom has been carried out by means of conformational energy computations for all naturally occurring amino acids and for a-aminobutyric acid when th
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A straightforward synthesis of 2,6‐disubstituted piperidines bearing α‐amino acid side‐chains was developed. Synthesis was based on a Horner−Wadsworth−Emmons condensation of a β‐ketophosphonate derived from an α‐amino acid residue with a β‐homologated aldehyde of an __N__‐protected amin