✍ Scribed by Ronald R. Burnette; Kenneth A. Connors
No coin nor oath required. For personal study only.
Literature values of ⌬G°(change in Gibbs free energy), ⌬H°(change in enthalpy), and T⌬S°(temperature times change in entropy) for 1:1 complex formation by ␣-, -, and ␥-cyclodextrins constitute normally distributed populations with the following statistical parameters (all energy quantities in kcal mol -1 ; n is the number of data points; is the population mean; is the standard deviation): for ␣-cyclodextrin, n ס 512, ⌬G ס -2.85, ⌬G ס 1.23, ⌬H ס -4.77, ⌬H ס 2.98, T⌬S ס -1.96, and T⌬S ס 2.72; for -cyclodextrin, n ס 415, ⌬G ס -3.67, ⌬G ס 1.37, ⌬H ס -4.24, ⌬H ס 2.89, ⌬S ס -0.56, and T⌬S ס 2.63; for ␥-cyclodextrin, n ס 42, ⌬G ס -3.71, ⌬G ס 1.19, ⌬H ס -3.10, ⌬H ס 3.39, T⌬S ס +0.69, and T⌬S ס 3.29. The temperature is 298.15 K. The mean ⌬G°values correspond to binding constants of 123, 490, and 525 M -1 for ␣-, -, and ␥-cyclodextrins, respectively.
📜 SIMILAR VOLUMES
The objective of this mini-review is to summarize the findings concerning the physicochemical properties and the pharmaceutical applications of acidic drugs whose performances have been modified by simultaneous complexation with cyclodextrins and salt formation. Particular attention is paid to the a