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Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications

✍ Scribed by Enrico Redenti; Lajos Szente; Josef Szejtli

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 120 KB
Volume: 90
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.1050

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✦ Synopsis

The objective of this mini-review is to summarize the findings concerning the physicochemical properties and the pharmaceutical applications of acidic drugs whose performances have been modified by simultaneous complexation with cyclodextrins and salt formation. Particular attention is paid to the approaches undertaken for increasing the solubility of the drugs by proper choice of the type of counterion analogously to what has been reported for complexes of basic drugs in the presence of hydroxy acids.

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