Consanguineous marriages, usually between first cousins or between uncle and niece, are common in certain societies. The transmission/disequilibrium test (TDT) compares the transmission from parents to an affected child of alleles at a marker locus, and differential transmission indicates linkage an
Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers
✍ Scribed by Dr. Heike Bickeböller; FrançOise Clerget-Darpoux
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 349 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
The transmissioddisequilibrium test (TDT) is extended in two ways for a multiallelic marker: (1) to compare transmitted and nontransmitted alleles from a single heterozygous parent and (2) to compare genotypes formed by the two transmitted alleles and genotypes formed by the two nontransmitted alleles using the information on both parents, heterozygous or not, simultaneously.
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Due in part to an influential paper by Risch and Merikangas [(1996) Science 273:1516-1517], which suggested that disequilibrium tests would have greater power to detect genes of small effect than would linkage tests, interest in the use of the Transmission Disequilibrium Test (TDT) as an analysis to
Family-based association tests such as the transmission-disequilibrium test (TDT), which compare alleles transmitted and non-transmitted from parents to affected offspring, are widely used to detect the role of genetic risk factors in diseases. These methods have the advantage of being robust to pop
Transmission disequilibrium test (TDT) is a nuclear family-based analysis that can test linkage in the presence of association. It has gained extensive attention in theoretical investigation and in practical application; in both cases, the accuracy and generality of the power computation of the TDT
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