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Investigation of the candidate genes ACTHR and Golf for bipolar illness by the transmission/disequilibrium test

✍ Scribed by Heike Bickeböller; Maria Kistler; Michael Scholz

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 37 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<575::aid-gepi4>3.0.co;2-z

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✦ Synopsis

Several versions of the transmission/disequilibrium test (TDT) were applied to the two candidate genes ACTHR and Golf for bipolar illness. Analyses were carried out separately for paternal and maternal transmission. Evidence for linkage and association was found for ACTHR for paternal transmission in support of a parent-of-origin effect. Possible evidence for segregation distortion was found for one of the two markers for Golf for maternal transmission.

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