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Statistical error mapping for reliable quantitative T1 imaging

✍ Scribed by Wilburn E. Reddick; Robert J. Ogg; R. Grant Steen; June S. Taylor

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
752 KB
Volume
6
Category
Article
ISSN
1053-1807

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✦ Synopsis

We developed a statistically based error image for rapid appreciation of unreliable reglons in quantitative water proton T1 images. The chi-squared error and coefficient of variation of the fltted parameter were used to estimate uncertainties in the goodness-of-fit to monoexponential T1 relaxation and the rellability of the calculated T1, respectively, for each pixel. Errors exceeding a statistical threshold based on a .1 acceptance criterion were displayed as a color-coded overlay on the T1 image. Error maps of quantitative T1 images from 31 healthy volunteers showed a characteristic error structure; few pixels within the parenchyma had excessive errors. Clinical cases with stroke and sickle cell disease showed deviations from the normal pattern in the spatial distribution and magnitude of chisquared errors. Disease states may deviate from monoexponential T1 relaxation more than normal brain does. The color-coded error map is a valuable tool for investigators using quantitative M R imaging to determine tissue relaxation parameters. Index terms: Magnetic resonance (MR). image processing -Magnetic resonance IMR). physics * Magnetic resonance IMR). relaxometry * Image. analysis -Computers. diagnostic aid JMRI lees: 1244-249 Abbreviations: CV = coeffirient of variation of the fitted parameter, IR = inversion recovery, PAIR = inversion recovery technique, TI = inversion recovery time, SI = signal intensity, CSF = cerebrospinal fluid, SNR = signalto-noise ratio, MCA = middle cerebral artery.

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