Fast high-resolution T1 mapping using inversion-recovery look-locker echo-planar imaging at steady state: Optimization for accuracy and reliability
✍ Scribed by Wanyong Shin; Hong Gu; Yihong Yang
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 993 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A fast T~1~ measurement sequence using inversion recovery Look‐Locker echo‐planar imaging at steady state (IR LL‐EPI SS) is presented. Delay time for a full magnetization recovery is not required in the sequence, saving acquisition time significantly for high‐resolution T~1~ mapping. Imaging parameters of the IR LL‐EPI SS sequence were optimized to minimize the bias from the excitation pulses imperfection and to maximize the accuracy and reliability of T~1~ measurements, which are critical for its applications. Compared with the conventional inversion recovery Look‐Locker echo‐planar imaging (IR LL‐EPI) sequence, IR LL‐EPI SS method preserves similar accuracy and reliability, while saving 20% in acquisition time. Optimized IR LL‐EPI SS provided quantitative T~1~ mapping with 1 × 1 × 4 mm^3^ resolution and whole‐brain coverage (28 slices) in approximately 4 min. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.