Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro
β Scribed by C. BANFI; M. BRIOSCHI; S. LENTO; A. PIRILLO; S. GALLI; S. COSENTINO; E. TREMOLI; L. MUSSONI
- Book ID
- 109154786
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 508 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1538-7933
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## Objective: To assess the ability of anti-proteinase 3 (anti-pr3) classic antineutrophil cytoplasmic antibodies (canca) to stimulate endothelial expression of tissue factor (tf), which is the main initiator of the coagulation cascade that can lead to endothelial injury and thrombosis in patients
The effects were examined of baicalein on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) production stimulated by interleukin-1β£ (IL-1β€) and tumour necrosis factor-β£ (TNF-β£) in cultured human vein umbilical endothelial cells (HUVECs). IL-1β€ and TNF-β£ increased