State of oncomarker protein B23/nucleophosmin in HeLa cells
β Scribed by N. M. Vladimirova; N. V. Lobanova; N. A. Potapenko
- Book ID
- 110155407
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 270 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0006-2979
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## Abstract The steadyβstate mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)βinduced cell killing. A block in G~2~/M phase, larger peak of apoptotic cells and higher caspaseβ3 __in vitro__ activity w
Localization of protein 823 in HeLa cells under different growth conditions was studied using indirect immunofluorescence. Bright nucleolar fluorescence was observed in exponentially growing cells. After 3 to 4 days, the initial cell inocula entered a phase of stationary growth as defined by no incr