Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
State of Adenomatous Polyposis Coli Gene and ras Oncogenes in Japanese Prostate Cancer
β Scribed by Suzuki, Hiroyoshi ;Aida, Sara ;Akimoto, Susumu ;Igarashi, Tatsuo ;Yatani, Ryuichi ;Shimazaki, Jun
- Book ID
- 108580951
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1994
- Tongue
- English
- Weight
- 402 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0910-5050
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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm