Interleukin-4 inhibits RANKL-induced NFA
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Jing Cheng; Jianzhong Liu; Zhenqi Shi; Duorong Xu; Shaokai Luo; Gene P. Siegal;
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Article
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2011
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John Wiley and Sons
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English
โ 532 KB
## Abstract Interleukinโ4 (ILโ4) is an important immune regulatory protein that possesses potent antiโosteoclastogenic properties, and does so via the transcription factor STAT6. Previous studies have shown that ILโ4 selectively blocks RANKLโinduced activation of NFโฮบB and mitogenโactivated protein