The essential regulators in the pathogenesis of classical Hodgkin lymphoma (cHL) are still largely unknown. The malignant Hodgkin/Reed-Sternberg (HRS) cells of cHL secrete various cytokines leading to the activation of signaling pathways such as the Janus kinase (JAK)/signal transducer and activator
✦ LIBER ✦
STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line
✍ Scribed by Baus, D; Nonnenmacher, F; Jankowski, S; Döring, C; Bräutigam, C; Frank, M; Hansmann, M-L; Pfitzner, E
- Book ID
- 109886849
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 407 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Many genes implicated in Th1 and Th2 differentiation have been identified in both human and mouse. However, the functional roles and hierarchy of these factors in the signaling pathways leading to either Th1 or Th2 responses are less clear. To explore at which stage of polarization the