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Stat5b (Signal Transducer and Activator of Transcription 5b), Not Stat5a, Is a Critical Modulator of Human Treg Development and Function

✍ Scribed by Jenks, J.; Seki, S.; Huang, J.; Nath, R.; Madmedov, M.; Hwa, V.; Rosenfeld, R.; Nadeau, K.C.

Book ID
119286512
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
38 KB
Volume
129
Category
Article
ISSN
1097-6825

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Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that