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Characterization of the human STAT5A and STAT5B promoters: evidence of a positive and negative mechanism of transcriptional regulation

✍ Scribed by Stefania Crispi; Emma Sanzari; Jlenia Monfregola; Nicola De Felice; Giorgia Fimiani; Raffaele Ambrosio; Michele D’Urso; Matilde Valeria Ursini

Book ID
117106322
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
481 KB
Volume
562
Category
Article
ISSN
0014-5793

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Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that