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STAT3 modulates the DNA damage response pathway

✍ Scribed by Seán P. Barry; Paul A. Townsend; Richard A. Knight; Tiziano M. Scarabelli; David S. Latchman; Anastasis Stephanou

Book ID
108785960
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
261 KB
Volume
91
Category
Article
ISSN
0959-9673

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## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe