✦ LIBER ✦

Standardization of Models and Methods Used to Assess Nanoparticles in Cardiovascular Applications

✍ Scribed by Kathleen T. Fitzgerald; Carolyn A. Holladay; Cathal McCarthy; Karen A. Power; Abhay Pandit; William M. Gallagher

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 485 KB
Volume: 7
Category: Article
ISSN: 1613-6810
DOI: 10.1002/smll.201001347

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Nanotechnology has the potential to revolutionize the management and treatment of cardiovascular disease. Controlled drug delivery and nanoparticle‐based molecular imaging agents have advanced cardiovascular disease therapy and diagnosis. However, the delivery vehicles (dendrimers, nanocrystals, nanotubes, nanoparticles, nanoshells, etc.), as well as the model systems that are used to mimic human cardiac disease, should be questioned in relation to their suitability. This review focuses on the variations of the biological assays and preclinical models that are currently being used to study the biocompatibility and suitability of nanomaterials in cardiovascular applications. There is a need to standardize appropriate models and methods that will promote the development of novel nanomaterial‐based cardiovascular therapies.

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