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Stable isotopes in obesity research

✍ Scribed by Gregory G. Dolnikowski; Julian B. Marsh; Sai Krupa Das; Francine K. Welty

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
194 KB
Volume
24
Category
Article
ISSN
0277-7037

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✦ Synopsis

Abstract

Obesity is recognized as a major public health problem. Obesity is a multifactorial disease and is often associated with a wide range of comorbidities including hypertension, non‐insulin dependent (Type II) diabetes mellitus, and cardiovascular disease, all of which contribute to morbidity and mortality. This review deals with stable isotope mass spectrometric methods and the application of stable isotopes to metabolic studies of obesity. Body composition and total energy expenditure (TEE) can be measured by mass spectrometry using stable isotope labeled water, and the metabolism of protein, lipid, and carbohydrate can be measured using appropriate labeled tracer molecules. Β© 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:311–327, 2005

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