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Stable isotope-assisted metabolomics in cancer research

✍ Scribed by Andrew N. Lane; Teresa W.-M. Fan; Richard M. Higashi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
222 KB
Volume
60
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon (^13^C) and nitrogen (^15^N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non‐cancerous cells, which can lead to new diagnostic tools. © 2008 IUBMB IUBMB Life, 60(2): 124–129, 2008

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