Stabilization of the DNA I-Motif Structure by Incorporation of 3′-S-Phosphorothiolate Linkages
✍ Scribed by John A. Brazier; Julie Fisher; Richard Cosstick
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 183 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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## Abstract Widely dispersed in genomic DNA, the tandem C‐rich repetitive stretches may fold below physiological pH, into i‐motif structures, stabilized by C·C^+^ pairing. Herein, structural status of a 9‐mer stretch d(CCCTAACCC), [the truncated double repeat of human telomeric sequence], and its e
## Abstract Cytosine‐rich DNA at low pH adopts an antiparallel tetraplex structure via the intercalation of two partially protonated, parallel stranded duplexes. This intriguing structural motif has been named i‐DNA. We have used a combination of spectroscopic and calorimetric techniques to charact