Stabilization of Proline Enamine Carboxylates by Amine Bases
✍ Scribed by Dr. Markus B. Schmid; Dr. Kirsten Zeitler; Prof. Dr. Ruth M. Gschwind
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 954 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0947-6539
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In the native state of proteins there is a marked tendency for an aromatic amino acid to precede a cis proline. There are also significant differences between the three aromatic amino acids with Tyr exhibiting a noticeably higher propensity than Phe or Trp to precede a cis proline residue. In order
Theoretical evidence now suggests that the mechanism of the longdebated Hajos-Parrish-Eder-Sauer-Wiechert reaction, the prototype for asymmetric organocatalytic reactions, involves a proline enamine intermediate (center) which undergoes a concerted aldol cyclization with proton transfer. For more de