Computational Evidence for the Enamine M
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Fernando R. Clemente; K. N. Houk
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Article
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2004
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John Wiley and Sons
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English
β 336 KB
Theoretical evidence now suggests that the mechanism of the longdebated Hajos-Parrish-Eder-Sauer-Wiechert reaction, the prototype for asymmetric organocatalytic reactions, involves a proline enamine intermediate (center) which undergoes a concerted aldol cyclization with proton transfer. For more de