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Stability of perfluorocarbon blood substitutes determined by sedimentation field-flow fractionation

✍ Scribed by Feng-Shyang Yang; Karin D. Caldwell; J.Calvin Giddings; Lynn Astle

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
626 KB
Volume
138
Category
Article
ISSN
0003-2697

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✦ Synopsis

It is shown that the method known as sedimentation field-flow fractionation, which has been applied to the separation and characterization of many industrial and biological particles and recently to emulsions, can be used to obtain high-resolution dropiet diameter profiles for perfluorocarbon blood substitutes. Following a description of the methodology, experiments are described for two commercial pertluorocarbon emulsions, Fluosol-DA 20% and Fluosol-43. The droplet diameter profiles for both of these blood substitutes are shown to shift to noticeably higher diameter values in less than 2 months. The diameter at the profile peak for Ruosol-DA 20'S, for example, shifts from 0.19 to 0.27 pm in 56 days.

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