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Stability measurements of antisense oligonucleotides by capillary gel electrophoresis

✍ Scribed by Gerard J.M. Bruin; K. Olaf Börnsen; Dieter Hüsken; Ernst Gassmann; H. Michael Widmer; Aran Paulus


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
820 KB
Volume
709
Category
Article
ISSN
1873-3778

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## Abstract Diffusion coefficients of oligonucleotides have been measured in polyacrylamide gel capillaries without application of an electrical field. A relationship between such diffusion coefficients and molecular size of the oligonucleotides could be achieved. The slower diffusion of larger oli