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Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)- ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative

✍ Scribed by Ronald Gust; Beate Schnurr; Rudolf Krauser; Günther Bernhardt; Marion Koch; Beate Schmid; Evelyn Hummel; Helmut Schönenberger


Book ID
106124748
Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
386 KB
Volume
124
Category
Article
ISSN
1432-1335

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The development of a galenical formulation for poorly water soluble dichloroplatinum(I1) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+)-1,2-bis(4-fluorophenyI)ethyle- nediamine]dichloroplatinum(II) (rac-4F-PtClz),