Sry and Sox9: mammalian testis-determining genes

✍ Scribed by Koopman, P.

• Book ID: 113013086
• Publisher: Springer
• Year: 1999
• Tongue: English
• Weight: 466 KB
• Volume: 55
• Category: Article
• ISSN: 1420-682X
• DOI: 10.1007/pl00013200

✦ Synopsis

Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian em-Sox9, which encodes a transcription factor related to Sry by the HMG box. Like Sry, mutations in Sox9 bryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to disrupt male development, but unlike Sry, the role of Sox9 is not limited to mammals. This review focuses bind to specific target sequences in DNA and to cause a bend in the chromatin. DNA bending appears to be on what is known about the two genes and their likely modes of action, and draws together recent data part of the mechanism by which Sry influences transcription of genes downstream in a cascade of gene relating to how they might interconnect with the network of gene activity implicated in testis determina-regulation leading to maleness, but the direct targets of Sry remain to be positively identified. One gene tion in mammals.