The SRY gene on the mammalian Y chromosome undoubtedly acts to determine testis, but it is still quite unclear how. It was originally supposed that SRY acts directly to activate other genes in the testis-determining pathway. This paper presents an alternative hypothesis that SRY functions indirectly
Mutations in SRY and SOX9: Testis-determining genes
β Scribed by Fergus J. Cameron; Andrew H. Sinclair
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 166 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1059-7794
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A familial mutation in SRY, the gene coding for the testis-determining factor TDF, was identified in an XY female with gonadal dysgenesis, her father, her two brothers and her uncle. The mutation consists of a T to C transition in the region of the SRY gene coding for a protein motif known as the hi
## Abstract The testisβdetermining factor in the mouse is encoded by the __Sry__ gene on the Y chromosome. Transcripts of this gene have been shown previously to be present in the genital ridge at the beginning of gonadal differentiation (11.5 days post coitum) and in adult testis. In this study, R
The sex-determining gene SRY was screened for molecular alteration in an XY sex-reversed female by single-strand conformation polymorphism (SSCP) technique. An A-to-G transition was detected which leads to an exchange of a tyrosine by a cysteine in the SRY protein. The affected tyrosine residue loca