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SREBPs: Transcriptional Mediators of Lipid Homeostasis

✍ Scribed by HORTON, J.D.; GOLDSTEIN, J.L.; BROWN, M.S.

Book ID
118012403
Publisher
Cold Spring Harbor Laboratory Press
Year
2002
Tongue
English
Weight
282 KB
Volume
67
Category
Article
ISSN
0091-7451

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Insulin has long-term effects on glucose and lipid metabolism through its control on the expression of specific genes. In insulin sensitive tissues and particularly in the liver, the transcription factor sterol regulatory element binding protein-1c (SREBP-1c) transduces the insulin signal. SREBP-1c