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Squamous cell carcinoma arising in Hailey–Hailey disease of the vulva

✍ Scribed by S.E. Cockayne; D.M. Rassl; S.E. Thomas

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
511 KB
Volume
142
Category
Article
ISSN
0007-0963

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✦ Synopsis

Abstract

A 61–year-old woman, who was known to have Hailey–Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This may be another example of chronic inflammation of the vulval area leading to the development of squamous cell carcinoma. However, in this case, chronic human papillomavirus may also have played a part, leading to VIN and reactivation of the Hailey–Hailey disease. We can find no previous reports of squamous cell carcinoma developing in the setting of Hailey–Hailey disease.

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