Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells
β Scribed by Yin-Hsun Feng; Chao-Jung Tsao; Chao-Liang Wu; Jan-Gowth Chang; Pei-Jung Lu; Kun-Tu Yeh; Gia-Shing Shieh; Ai-Li Shiau; Jeng-Chang Lee
- Book ID
- 108586795
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 521 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1347-9032
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## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cellβsurface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcriptionβpolymerase chain reaction
## Abstract Recently, mutations in the __epidermal growth factor receptor__ (__EGFR__) gene in nonsmall cell lung cancer (NSCLC) patients were reported to correlate with gefitinib response. Less than 30% of NSCLC patients are surgically resectable; however, molecular analysis has to rely on nonsurg