Spotlights on our sister journals: Chem. Eur. J. 5/2008

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 356 KB
• Volume: 14
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200890012

✦ Synopsis

GRL-06579A, an HIV-1 protease inhibitor, can be synthesized with the aid of heterobimetallic multifunctional catalysts. The key steps are an ALB-catalyzed Michael reaction and an LLB-catalyzed diastereoselective nitroaldol reaction. ALB = Al-Libis(binaphthoxide), LLB = La-Li 3tris(binaphthoxide), TBS = tert-butyldimethylsilyl.