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Spotlights on our sister journals: Chem. Eur. J. 1/2008

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 427 KB
Volume: 14
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200790144

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GRL-06579A, an HIV-1 protease inhibitor, can be synthesized with the aid of heterobimetallic multifunctional catalysts. The key steps are an ALB-catalyzed Michael reaction and an LLB-catalyzed diastereoselective nitroaldol reaction. ALB = Al-Libis(binaphthoxide), LLB = La-Li 3tris(binaphthoxide), TB