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Spontaneous Reversal of P-Glycoprotein Expression in Multidrug Resistant Cell Lines*

✍ Scribed by Green, Henrik ;Lotfi, Kourosh ;Zackrisson, Anna-Lena ;Peterson, Curt

Book ID
111262696
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
273 KB
Volume
93
Category
Article
ISSN
0901-9928

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## Abstract Multi drug resistance (MDR) in tumor cells is frequently associated with reduced cellular cytostatic drug accumulation, caused by the drug efflux protein, P‐glycoprotein (Pgp). The action of Pgp in tumor cells can be detected by measuring the increase of daunorubicin accumulation upon b