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Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

✍ Scribed by Riordan, John R.; Deuchars, Kathryn; Kartner, Norbert; Alon, Noa; Trent, Jeffrey; Ling, Victor

Book ID
109741048
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
435 KB
Volume
316
Category
Article
ISSN
0028-0836

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## Abstract Multi drug resistance (MDR) in tumor cells is frequently associated with reduced cellular cytostatic drug accumulation, caused by the drug efflux protein, P‐glycoprotein (Pgp). The action of Pgp in tumor cells can be detected by measuring the increase of daunorubicin accumulation upon b