Spontaneous resolution of isolated thymic langerhans cell histiocytosis
โ Scribed by Elliott, Martin ;Kokai, George K. ;Abernethy, Laurence J. ;Pizer, Barry L.
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 109 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0098-1532
- DOI
- 10.1002/mpo.1324
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Background. Because prostaglandin (PG) E2 has been identified in the bone lesions of Langerhans cell histiocytosis (LCH), we speculated that indomethacin, a potent PG inhibitor, may be useful in patients with symptomatic LCH involving the bony skeleton. Procedure. We used indomethacin to treat patie
Langerhans' cell histiocytosis (LCH) is characterized by an accumulation and/or proliferation of cells with a Langerhans' cell (LC) phenotype. The aetiology and pathogenesis of LCH are unknown; it is suggested that LCH is caused by an immunological dysregulation. Production of cytokines is a central