✦ LIBER ✦

Spontaneous myopathy in the SJL/J mouse: Pathology and strength loss

✍ Scribed by Ann H. Weller; Susan A. Magliato; Katherine P. Bell; Neil L. Rosenberg

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 437 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199701)20:1<72::aid-mus10>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

Myopathy has been found to develop spontaneously in 100% of SJL/J mice between 6 and 8 months of age. Extent of muscular involvement and mouse strength were quantified in SJL/J mice and Balb/c control mice 2-16 months old. Muscle from young SJL/J mice exhibited histopathological abnormalities and occasional inflammatory infiltrate. By 6 months, 78% of SJL/J mice had developed active myopathy. By 8 months, all SJL/J mice examined had active disease with a mean of 12.9% of muscle fibers affected. Replacement of muscle fibers by fat and/or collagen began at 10 months and was pronounced by 14 months. Significant decreases in strength scores (total body pulling force) at 6 months and 10 months of age reflected the onset of active myopathy and the onset of muscle degeneration, respectively. The spontaneous onset and 100% incidence of myopathy in the SJL/J mouse line should provide a useful model for idiopathic myopathy.

📜 SIMILAR VOLUMES

New observations on hair loss in the hai

New observations on hair loss in the hairless mouse

✍ Mann, Stanley J. ;Straile, William E. 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB 👁 1 views

Grip strength: A measure of the proporti

Grip strength: A measure of the proportion of protein loss in surgical patients

✍ J. A. Windsor; Professor G. L. Hill 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 2 views

Limb reduction defects in the A/J mouse

Limb reduction defects in the A/J mouse strain associated with maternal blood loss

✍ Fawcett, Lynda B.; Buck, Susan J.; Brent, Robert L. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB

We previously described a high incidence of digit/limb anomalies in the offspring of A/J mice subjected to surgery on day 12.5 postconception (p.c.), but not in the offspring of untreated control mice. To investigate the cause of these defects, we compared the offspring of mice in experimental group

Quadriceps strength and the risk of cart

Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis

✍ Shreyasee Amin; Kristin Baker; Jingbo Niu; Margaret Clancy; Joyce Goggins; Ali G 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 2 views

A follow-up study of the progression or

A follow-up study of the progression or spontaneous regression of leukemia in mouse strains

✍ J. Szöllösi; I. Ember; L. Trón; P. Kertai 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 465 KB

## Abstract C3H/He‐mg and AKR mice were injected intraperitoneally with lymphocytes prepared from the spleen of (C3H/He‐mg X AKR)F~1~ hybrid mice bearing Gross‐virus leukemia. Lymphocyte suspensions were prepared from the spleen, mesenteric lymph node and thymus of mice at different days after the

The genetic background modifies the spon

The genetic background modifies the spontaneous and X-ray–induced tumor spectrum in the Apc1638N mouse model

✍ C. Willemien van der Houven van Oordt; Ron Smits; Theo G. Schouten; Jeanine J. H 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB 👁 1 views

The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrlBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Simil