The genetic background modifies the spontaneous and X-ray–induced tumor spectrum in the Apc1638N mouse model
✍ Scribed by C. Willemien van der Houven van Oordt; Ron Smits; Theo G. Schouten; Jeanine J. Houwing-Duistermaat; Sophia L.H. Williamson; Arne Luz; P. Meera Khan; Alex J. van der Eb; Marco L. Breuer; Riccardo Fodde
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 293 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrlBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc Min model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.