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Spontaneous healing of Langerhans cell histiocytosis (histiocytosis X)

✍ Scribed by L. Corbeel; E. Eggermont; J. Desmyter; I. Surmont; R. Vos; C. Wolf-Peeters; C. Cobbaert; A. Eykens

Publisher: Springer
Year: 1988
Tongue: English
Weight: 278 KB
Volume: 148
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00441809

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✦ Synopsis

A 3-month-old male infant presented with pallor, hepatomegaly (4.5 cm), splenomegaly (1.5 cm), anaemia (Hb 6 g/dl) and thrombocytopenia (16 X 10(9)/l). A liver biopsy was diagnostic for Langerhans cell histiocytosis (histiocytosis X). The patient's lymphocytes, co-cultured with neonatal lymphocytes, were positive for virus-like particles without reverse transcriptase activity. The hepatomegaly diminished after 6 months and a second liver biopsy showed decreased histiocytic infiltration. A second viral blood culture remained negative. After 14 months, the hepatomegaly had disappeared completely and there were no more abnormal haematological or clinical findings.

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