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Spontaneous development of a chromosomal translocation 5;14 in an epstein-barr-virus-associated b-cell lymphoma in a SCID mouse

โœ Scribed by Ronald Glaser; Karl S. Theil; Robert H. Bonneau; John F. Sheridan; Marco Vasquez; Carl M. Allen

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
848 KB
Volume
55
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

C.B-I7 SCID mice were inoculated with human peripheral blood leukocytes (PBLs) from normal Epstein-Barr virus (EBV)seropositive and -seronegative donors. Confirmation of a functioning human immune response was demonstrated by the detection of human antibody after inoculation with rotavirus, tetanus toxoid, or EBV. One group of animals inoculated with PBLs from an EBV-seropositive donor developed immunoblastic lymphomas approximately 9 weeks after transplantation. Confirmation of the species and sex of origin of the tumor cells was established using a spontaneous cell line prepared from the tumor. At passage I, the tumor-cell line (AGTI) showed 15% of the metaphases with a translocation involving chromosomes 5 and 14. A lymphoblastoid cell line (AGLCL) established from the

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