CLINICOPATHOLOGICAL, IMMUNOLOGICAL AND GENETIC STUDIES OF CD30+ ANAPLASTIC LARGE CELL LYMPHOMA OF B-CELL TYPE; ASSOCIATION WITH EPSTEIN-BARR VIRUS IN A JAPANESE POPULATION
✍ Scribed by KUZE, TETUO; NAKAMURA, NAOYA; HASHIMOTO, YUKO; ABE, MASAFUMI; WAKASA, HARUKI
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 732 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0022-3417
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✦ Synopsis
The clinicopathological features, the immunophenotype, and the presence of Epstein-Barr virus (EBV)-associated genomes and gene products were examined in 17 cases of CD30+ anaplastic large cell lymphoma (ALCL) of B-cell type. Microscopically, the 17 cases were divided into ten cases of the monomorphic type and seven cases of the pleomorphic type. EBV was detected in 6 of 17 cases (38 per cent) by RNA in s i ~u hybridization (ISH) with EBV-encoded RNA (EBERl). EBER1+ cases consisted of two cases (20 per cent) of the monomorphic type and four cases (57 per cent) of the pleomorphic type. The five EBERl+ cases showed clonality of the EBV genome by Southern blotting, consistent with the presence of EBV in a monoclonal proliferation. The EBV-encoded latent membrane protein 1 (LMP1) was found in all six EBERl+ cases and EBV-encoded nuclear antigen 2 (EBNA2) was present in two cases by immunohistochemistry. No expression of LMPl or EBNAZ was observed in the EBERlcases. The EBERl + cases had a tendency for a more favourable prognosis than the EBERl ~-cases. It is concluded that EBV has an association with CD30' ALCL of B-cell type in the Japanese population studied, and especially with the large pleomorphic type. EBV infection may play a pathoaetiological role and may influence clinical behaviour.