Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
✍ Scribed by Harvey, Michele; McArthur, Mark J.; Montgomery, Charles A.; Butel, Janet S.; Bradley, Allan; Donehower, Lawrence A.
- Book ID
- 109918541
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 560 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1061-4036
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## Abstract Mice with disrupted germline __p53__ alleles have been engineered by us and others and have been shown to have enhanced susceptibility to spontaneous tumors of various types. We monitored a large number of __p53__‐deficient mice(__p53__+/− and __p53__−/−) and their wild‐type littermates
## Abstract To determine whether a constitutive __p53__ deficiency would enhance the rate of development of chemically induced hepatocellular carcinoma, we treated groups of wild‐type, __p53__‐heterozygous (+/‐), and null (‐/‐) male mice with a single dose of diethylnitrosamine at 12 d of age. Alth
Mice lacking both p18 Ink4c and p27 Kip1 develop a tumor spectrum similar to pRb þ/À mice, and loss of p53 function accelerates tumorigenesis in pRb þ/À mice. We hypothesized that codeletion of either p18 or p27 in conjunction with p53 deletion will also accelerate tumorigenesis. Mice lacking both p