Spongistatin synthetic studies. 1. Construction of a C(29–48) subtarget
✍ Scribed by Amos B. Smith III; Linghang Zhuang; Christopher S. Brook; Armen M. Boldi; Mark D. McBriar; William H. Moser; Noriaki Murase; Kiyoshi Nakayama; Patrick R. Verhoest; Qiyan Lin
- Book ID
- 108386391
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 270 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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A convergent synthesis of the C(1-17) AB-ring subunit of the spongistatins, exceedingly scarce and highly ant]mitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulfone coupling/methylenation. © ]997 Elsevier Science
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