Split hand foot malformation (SHFM): An introduction
β Scribed by Alan L. Shanske
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 68 KB
- Volume
- 140A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract **BACKGROUND:** Split hand foot malformation (SHFM) (cleft hand, central ray deficiency) is a highly variable malformation that shows genetic heterogeneity with at least five loci mapped to date. SHFM occurs as an isolated finding or in association with other anomalies, including congen
## Abstract The split hand/foot malformation is a developmental defect of the extremities resulting from errors in the initiation and maintenance of the apical ectodermal ridge. The phenotype is genetically heterogeneous, and it can be identified either as an isolated phenotypic manifestation or as