Splenectomy and chemotherapy in acute myelocytic leukemia of childhood
โ Scribed by Irvin Fleming; Joseph Simone; Rudolph Jackson; Warren Johnson; Thomas Walters; Clara Mason
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 827 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3
## Preisler Reporting of clinical failures using this schema would focus attention on the mechanism of treatment failure and hence lead t o logically derived successor studies For example, given two therapeutic regimens each of which produces a 50% complete remission rate, if tlie failures in one