Failure of remission induction in acute myelocytic leukemia

✍ Scribed by Preisler, Harvey D.

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 107 KB
• Volume: 4
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950040311

✦ Synopsis

Preisler

Reporting of clinical failures using this schema would focus attention on the mechanism of treatment failure and hence lead t o logically derived successor studies For example, given two therapeutic regimens each of which produces a 50% complete remission rate, if tlie failures in one are all Type I and the failures in the other are all Type IV, the subsequent modifications of each regimen would lead in tlie former to an increase in dose levels and in the latter, by contrast, a decrease. Furthermore, using the proposed classification schema, it becomes readily apparent that the mechanism of treatment failure in the initial therapy of this disease is different from that in the treatment of relapsed disease, since in the former almost all induction failures are Type IV and V, while in the latter most are Type 1 and Type 11 failures.